Research Associate II, Process Development

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SUMMARY: Icosavax, Inc., a member of the AstraZeneca Group (LSE/STO/Nasdaq: AZN), is a biopharmaceutical company focused on developing differentiated, high-potential vaccines using an innovative, protein virus-like particle (VLP) platform. Icosavax’s VLP platform technology is designed to enable multivalent, particle-based display of complex viral antigens, which it believes will induce broad, robust, and durable protection against the specific viruses targeted. Icosavax’s pipeline includes vaccine candidates targeting respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). Based in Seattle, Icosavax was formed in 2017 to advance the breakthrough VLP technology with the goal to discover, develop, and commercialize vaccines against infectious diseases. In 2024, AstraZeneca acquired Icosavax, Inc. AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology.
Icosavax seeks a Research Associate II with a background in general lab operations and downstream process development to advance our clinical manufacturing programs. The primary focus of the position will involve general lab support and downstream process development of recombinant proteins.
JOB DUTIES
·       Execute small-scale protein purification using Akta systems and a wide range of column chromatography techniques.
·       Characterize recombinant proteins using biophysical techniques including UV-Vis, SDS-PAGE, HPLC and BLI.
·       Capture primary data and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
·       Conduct essential lab functions including buffer preparation, ordering, shipping and equipment operation/maintenance.
·       Assist in authoring SOPs, methods and technical reports.
·       Effectively communicate experimental design and results to supervisor and/or project teams.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: 
·       BS degree in life sciences
·       2+ years industry experience
·       Experience with chromatographic purification of recombinant proteins
·       Experience with general day-to-day lab operations
·       Practical knowledge with analytical characterization of recombinant proteins
·       Excellent organizational and verbal/written communication skills
·       Demonstrated proficiency in data analysis and verbal and written technical communication
 
PHYSICAL DEMANDS: 
·       Manual dexterity required to operate office and lab equipment.
OTHER:
·       Location: Seattle, WA
·       Must be eligible to work in the USA
·       To reduce the presence and severity of COVID-19 cases in the workplace and in our communities, Icosavax requires all newly hired employees to be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state and local law.
The salary range for this position is $80,000 – $90,000 per year; the base salary will be determined based on knowledge, skills, education, and experience relevant to the role. Employees are offered health insurance (medical, dental, vision), health savings account with company contribution, flexible spending account, life insurance, short- and long-term disability, 401(K) plan with company contribution, vacation, sick and safe time, company holidays and floating holidays.

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